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Prevalence of Anabolic Steroids use among adult females

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Prevalence of Anabolic Steroids use among adult females

Posted on 01 September 2010 by admin

Research suggests that a smaller number of adult females use AS than males (Korkia and Stimson, 1993; Lenehan et al., 1996). As yet there are no studies that provide reasons for this difference, and studies regarding the prevalence of AS use among females are scarce. It may be that societal issues such as perceptions of the ‘ideal’ female body image are related to the lower frequency in the population of female AS users. Other factors that may be related to the lower use of AS may include the reluctance of females to be seen as using methods of doping, particularly those methods, such as use of AS, that are associated with potentially masculinizing side-effects.

Since AS were first synthesized, the roles of women have undergone a series of changes. The 1960s saw a new attitude towards many ‘old’ values. It is speculated that the first females to use AS for enhancement of sporting performance were elite-level athletes from the Eastern Bloc countries (Yesalis et al., 1993b). Positive tests for AS have been  reported for a number of females in sporting competitions ( Jennings, 1996; Wallechinsky, 1996). However, studies into use of AS by women are infrequent. The number of women that want to be involved in research might be small as a  result of reluctance of women to admit to drug use (Strauss et al., 1985; Korkia et al., 1996), and it might be that this is related to issues of child care and the traditional feminine image (Duda, 1986b).

Conventional and media representations of the ‘ideal’ female body tend not to be well muscled (Lenskyj, 1986;  Cashmore, 1990). Muscles are generally equated with masculinity (Rosenkrantz et al., 1968) and females involved in
stereotypically masculine sports are not viewed positively (Kane and Snyder, 1989). However, since the 1960s  women’s roles have become more varied and the women’s movement has been influential in the struggle against the
stereotyping of females. Women are now able to compete in a wide variety of sports and to pursue careers that were previously restricted to males.

A range of occupations in which strength and muscularity are desirable have now become viable career options for women. These women are now under the same pressure as men not to be tempted into using AS to improve their ability to perform in their job. Occupations such as the armed forces, in which females may now be in active combat, and the security business, where females may be employed as door staff and security guards, are pertinent examples.

The medical uses of AS in the treatment of women are diverse. These drugs have been used to treat female to male transsexuals (Westaby et al., 1977), and for the treatment of a variety of disorders. Anabolic steroids and other testosterone-derived treatments carry the risk to females of permanent sideeffects such as deepening of the voice, clitoral enlargement, increased growth of facial and body hair and reduction in breast size (Strauss et al., 1985; Korkia et al., 1996), and this has led to their limited use in the treatment of women. The principle behind the use of  testosterone and testosteronederived drugs is that these substances may neutralize the effects of oestrogen. Hoberman and Yesalis (1995) report that advertisements for male hormone treatment have been included in medical journals since the early 1920s, when these treatments were used in attempts to alleviate female conditions such as menstrual problems and breast conditions, including tumours.

Testosterone therapy was used to treat women in the 1940s with breast cancer. These treatments are still used today for women suffering from post-menopausal androgen-dependent breast cancer (Hoberman and Yesalis, 1995). A  consequence of the research in the 1940s was that it was observed that the testosterone treatment served to increase the women’s sex drive, appetite and general feelings of well-being. Testosterone therapies were also used to increase the libido in women, but this type of treatment is not current standard medical practice.

As mentioned previously, the number of adolescent females using AS appears to be increasing at a faster rate than any other group of AS users (Yesalis et al., 1997). Other studies of the prevalence of AS use among adolescents have also documented the use of AS by female adolescents (Handelsman and Gupta, 1997; Faigenbaum et al., 1998; Lambert et al., 1998). This is particularly worrying because this group of users may be at a high risk of developing adverse  symptoms as a consequence of their AS use, some of which may be irreversible, such as deepening of the voice and clitoral enlargement (Strauss et al., 1985). It has been claimed that females are more sensitive to AS than males  (Buckley et al., 1988); the basis of this claim stems from the fact that AS are derivatives of the male hormone testosterone, and this hormone is responsible for the development and maintenance of male secondary sexual characteristics and is found only in very small amounts in women.

Korkia and Stimson (1997) conducted a prevalence study involving 21 gyms in England, Scotland and Wales. They found that 2.3% of the women (N = 1667) had used AS in the past and 1.4% were currently using AS. A study of AS use in the north-west of England (Lenehan et al., 1996) showed that of the 386 respondents interviewed, all of whom were attending gyms in the area studied, seven were women. This is a small percentage of the total number of AS users, although it is representative only of those women that admitted to using AS. All of these women were involved in competitive body-building.

Body-building is frequently perceived to be a sport closely related to the use of AS (Ryan, 1981; Duda, 1986b; Tricker et al., 1989), and public perceptions of body-builders tend to be varied (Klein, 1984; Kane, 1988). The first female body-building competition was held in 1977 in Ohio, USA (Duff and Hong, 1984), and female body-building  competitions are now held in many countries around the world. There are a limited number of studies about female body-builders but ‘underground’ steroid handbooks, generally written by and for those involved in the AS-using  culture, seem to suggest that AS use is not restricted to male body-builders (Duchaine, 1989; Hart, 1993). Often these texts suggest that women use lower doses of AS than men.

A study of needle exchanges in the Merseyside and Cheshire regions of England showed that the number of female AS users attending needleexchange schemes had decreased between 1992 and 1996 (Birtles, 1998). This reduction in attendance presents a cause for concern as it may be representative of women feeling excluded from drug agencies. However, it may also reflect a reduction in the number of females using AS. Awiah et al. (1990) have also reported that many women drug users are reluctant to attend drug agencies. Studies have shown that certain females do inject AS (Strauss et al., 1985; Korkia et al., 1996), and thus the needle-exchange figures may be a misrepresentation of the actual numbers of females injecting AS.



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Effects of testosterone and related substances upon humans

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Effects of testosterone and related substances upon humans

Posted on 01 September 2010 by admin

A number of experiments were carried out in the nineteenth century by Brown-Sequard, a French physiologist, in which he injected the aqueous extracts from animal testes into himself as well as into a range of animals.

In 1889 Brown-Sequard reported his observations, declaring that he had reversed his own decline into old age. Although Brown-Sequard’s discoveries were not accepted because of the lack of experimental controls, his idea that
the testes release physiologically active substances proved to be true (Kochakian, 1993a). His self-experimentation provided the basis for further studies into the effects of ingestion of testicular extracts, and ultimately the effects of testosterone, upon people.

Surgeons developed the technique of transplanting human and animal (e.g. monkeys) testes into patients whose testes were damaged or dysfunctional.

Claims were made that these operations had relieved pain and discomfort and promoted bodily well-being in hundreds of patients. People began to seek treatment for all manner of disorders: senility, asthma, epilepsy, diabetes, impotence, tuberculosis, paranoia, gangrene and more (Hoberman and Yesalis, 1995).

However, this method of treatment was not accepted by the scientific community, who did not believe many of
the claims made. An international committee that was appointed to investigate these claims concluded that claims of rejuvenation as a result of testicular transplantation were unfounded (Parkes, 1985).

Subsequent to the research outlined above, testosterone has been isolated and its structure discovered.



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Human Chorionic Gonadotrophin (Injectable)

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Human Chorionic Gonadotrophin (Injectable)

Posted on 01 September 2010 by admin

Alternative names:

Choriogonadotrophin
Chorionic gonadotropin
Gonadotrophinum chorionicum
HCG
hCG
Pregnancy-urine hormone

Description

Human chorionic gonadotrophin (hCG) is a hormone produced by the placenta and obtained from the urine of pregnant women. Its effects are predominantly those of the gonadotrophin, luteinizing hormone, and it is used in the treatment of infertile women and in the treatment of delayed puberty in males.

Side-effects that have been reported include headache, tiredness, changes in mood, depression, restlessness, oedema, and pain on injection. There have also been links between hCG and gynaecomastia. hCG should be avoided in individuals for whom androgen-induced fluid retention might be a hazard; for example, those with asthma, epilepsy, migraine, cardiovascular disorders, hypertension and renal disorders. hCG should also be avoided in individuals
with disorders that might be exacerbated by androgen release, such as carcinoma of the prostate.

It is relatively common for Anabolic Steroids users to use hCG. It has been used to ‘kick-start’ the natural production of the hormones from the testes that had been suppressed by the higher levels of exogenous steroids. However, it is considered by some that the use of hCG merely carries this effect one more step down the homeostatic-controlled hormonal system.

Using hCG not only stimulates testosterone but will also suppress LHRF production from the pituitary. When hCG is stopped there will then be low LHRF leading to low LH levels that in turn will cause suppressed testes function. This  means that any benefits from using hCG would be lost in addition to the possibility of the pituitary gland being affected indefinitely.



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Sustanon 250 (Injectable)

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Sustanon 250 (Injectable)

Posted on 31 August 2010 by admin

Alternative names:

Sostenon 250
Sustenon 250

Veterinary products:

Deposterone

Therapeutic dose:

1 mL every 3 weeks

Description

Sustanon contains four different testosterones:
Testosterone propionate 30 mg
Testosterone phenylpropionate 60 mg
Testosterone isocaproate 60 mg
Testosterone decanoate 100 mg

Sustanon 250 has considerable anabolic and androgenic properties. It was designed to maximize the synergistic effect of using four testosterones. The variation in half-life times of the testosterones means that the product is fast-acting and remains effective for several weeks. Total plasma testosterone levels peak approximately 24–48 hours after administration. Plasma testosterone levels return to the lower limit of the normal range in males in approximately 21 days. Sustanon is predominantly used as testosterone  replacement therapy in the treatment of male hypogonadal disorders such as eunuchoidism (following castration), hypopituitarism, endocrine impotence, decreased libido and disorders of spermatogenesis. Testosterone therapy may also be indicated for the prevention and treatment of osteoporosis in hypogonadal males.

Street information

Sustanon 250 has a reputation for being very effective at increasing both size and strength. The adverse effects of water retention and aromatization leading to  gynaecomastia are considered to be less pronounced than in long-acting testosterone injections.



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